Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

BackgroundTumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has Hitches implicated alterations in chromatin structure as the mechanistic basis for this repression.In addition to DNA methylation, other epigenetic post-translational modifications that modulate the stability and binding of s

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Innovative Feature Extraction and Machine Learning Joint Approaches for Automated Detection of Focal Cortical Dysplasia Type II

Focal cortical dysplasia type II (FCD Security Monitors II) is an epileptogenic lesion often associated with pharmacoresistant epilepsy.Yet, owing to their subtle appearance, identifying these lesions via 3D Magnetic Resonance Image (MRI) remains a complex challenge, rendering them susceptible to evasion by conventional visual analysis.In this stud

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Cross-sectional study on the prevalence of contagious pathogens in bulk tank milk and their effects on somatic cell counts and milk yield

Data on the prevalence of major contagious pathogens in bulk tank milk (BTM) in Italy are generally not available.The availability of Real-Time PCR procedures (qPCR) to perform BTM analysis by represents an important step to define herd health status.Therefore, a cross-sectional epidemiological study was designed to assess the prevalence of contagi

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